Rheumatoid arthritis—common origins, divergent mechanisms
EM Gravallese, GS Firestein - New England Journal of Medicine, 2023 - Mass Medical Soc
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
IL-4 and IL-13: regulators and effectors of wound repair
JE Allen - Annual review of immunology, 2023 - annualreviews.org
Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
SK Wculek, I Heras-Murillo, A Mastrangelo, D Mañanes… - Immunity, 2023 - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …
Nonresolving inflammation redux
C Nathan - Immunity, 2022 - cell.com
Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
P Rodríguez-Morales, RA Franklin - Trends in Immunology, 2023 - cell.com
Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …
M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair
L Li, J Cao, S Li, T Cui, J Ni, H Zhang, Y Zhu… - Advanced …, 2023 - Wiley Online Library
Tissue‐resident cardiac macrophage subsets mediate cardiac tissue inflammation and
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …
repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing …
Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism
Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory
regulation in macrophages remains unclear. We generated mice that are deficient in both …
regulation in macrophages remains unclear. We generated mice that are deficient in both …
Biochemical and molecular inducers and modulators of M2 macrophage polarization in clinical perspective
V Kiseleva, P Vishnyakova, A Elchaninov… - International …, 2023 - Elsevier
Macrophages as innate immune cells with great plasticity are of great interest for cell
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …
Dual immune regulatory roles of interleukin-33 in pathological conditions
H Guo, EA Bossila, X Ma, C Zhao, Y Zhao - Cells, 2022 - mdpi.com
Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …