Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …

Autophagy is an intracellular degradation process responsible for the delivery of cellular
material to the lysosomes. One of the key mechanisms for control of autophagy is the …

The BCL-2 family of proteins integrates signals that trigger either cell survival or apoptosis.
The balance between pro-survival and pro-apoptotic proteins is important for tissue …

Sertoli cells regulate differentiation and development of the testis and are essential for
maintaining adult testis function. To model the effects of dysregulating Sertoli cell number …

The Sertoli cells are critical regulators of testis differentiation and development. In the adult,
however, their known function is restricted largely to maintenance of spermatogenesis. To …

Reproductive difficulties are associated intimately with cytogenetic abnormalities. This article
reviews multicolour fluorescence in situ hybridization studies on spermatozoa from men with …

The roles of FSH and androgen in the postnatal development of Sertoli cell number and
function have been investigated using mice that lack FSH (FSHβKO), FSH-receptors …

The blood-testis barrier (BTB) is known for its ability to create an immune privilege site in the
seminiferous epithelium, but less is known of the blood-epididymal barrier (BEB). It is …