Many recent epidemiological, clinical and experimental findings support the hypothesis that
environmental toxicants are responsible for the increasing male reproductive disorders …

Mice lacking TYRO3, AXL and MER (TAM) receptor tyrosine kinases (RTKs) are male sterile.
The mechanism of TAM RTKs in regulating male fertility remains unknown. In this study, we …

Previous studies have suggested that FSH may be involved in regulation of Leydig cell
function. We have examined this directly using two mouse models with null mutations in …

It has been shown that testicular germ cell development is critically dependent upon somatic
cell activity but, conversely, the extent to which germ cells normally regulate somatic cell …

Bfl-1 is a pro-survival Bcl-2 family member overexpressed in a subset of chemoresistant
tumours, including melanoma. Here, we characterised the expression and regulation of Bfl-1 …

The gerbil (Meriones unguiculatus) is a rodent native of the arid regions of Mongolia and
China. Because the gerbil can be easily bred in laboratory conditions, this species has been …

p, p′-Dichlorodiphenoxydichloroethylene (p, p′-DDE), the major metabolite of
dichlorodiphenoxytrichloroethane (DDT), is a known persistent organic pollutant and male …

Apoptosis is a process of cell suicide, the mechanisms of which are encoded in the
chromosomes of all nucleated cells. Apoptosis occurs spontaneously throughout …

Clinical findings and a variety of experimental models indicate that Leydig cell dysfunction
accompanies damage to the seminiferous tubules with increasing severity. Most studies …

Abstract Coxsackievirus B3 (CVB3) contributes to the development of myocarditis, an
inflammatory heart disease that predominates in males, and infection is a cause of …