Apoptosis is a process of cell suicide, the mechanisms of which are encoded in the
chromosomes of all nucleated cells. Apoptosis occurs spontaneously throughout …

The inverse relationship of testicular size and circulating follicle-stimulating hormone (FSH)
concentrations has been documented, and accompanying this relationship is the change in …

The reproductive system is extremely susceptible to environmental insults, for example
exogenous steroids during gestational development and differentiation. Experimental …

Retinoblastoma protein (RB) plays crucial roles in cell cycle control and cellular
differentiation. Specifically, RB impairs the G1 to S phase transition by acting as a repressor …

This study investigated the effect of spermatogonial stem cell encapsulated in alginate
hydrogel during cryopreservation, as cells were protected against damage during …

p, p′-DDE, the major metabolite of dichlorodiphenoxytrichloroethane (DDT), is a known
persistent organic pollutant and male reproductive toxicant. However, the mechanism …

Biomonitoring studies have shown that pregnant women living in regions of unconventional
natural gas (UNG) exploitation have higher levels of trace elements. Whether developmental …

Background Intrinsic pathway of apoptosis is generally mediated by BCL-2 (B cell lymphoma
2) family of proteins; they either induce or inhibit the apoptosis. Overexpression of BCL-2 in …

Peroxisomal testis-specific 1 gene (Pxt1) is the only male germ cell–specific gene that
encodes a peroxisomal protein known to date. To elucidate the role of Pxt1 in …

To explore physiological roles of BCL-W, a prosurvival member of the BCL-2 protein family,
we generated transgenic (TG) mice overexpressing Bcl-w driven by a chicken β-actin …