Male mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due
to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and …

Enrichment of spermatogonial stem cells (SSCs) from the mammalian adult testis faces
several limitations owing to their relatively low numbers among many types of advanced …

The lactocrine hypothesis suggests a mechanism whereby milk-borne bioactive factors
delivered to nursing offspring affect development of neonatal tissues. The objective of this …

OBJECTIVE: To localize the different proteins involved in the executioner step of apoptosis
in the human testicular tissue: effector caspases (3, 6, and 7), caspase inhibitors called …

During development in the mouse, two populations of Leydig cells arise sequentially. The
fetal Leydig cell population arises shortly after testicular differentiation and functions …

It has been shown that testicular germ cell development is critically dependent upon somatic
cell activity but, conversely, the extent to which germ cells normally regulate somatic cell …

Male mice homozygous for a mutated allele of the cyclin A1 gene (Ccna1) are sterile due to
a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1 …

Ectoplasmic specializations are actin filament-endoplasmic reticulum complexes that occur
in Sertoli cells at sites of intercellular attachment. At sites between inter-Sertoli cell …