Childhood obesity is, according to the WHO, one of the most serious challenges of the 21st
century. More than 100 million children have obesity today. Already during childhood …

Bone remodelling, which maintains bone mass constant during adulthood, is an energy-
demanding process. This, together with the observation that the adipocyte-derived hormone …

Osteoporosis and obesity are both major public health concerns. It has long been
considered that these are distinct disorders rarely found in the same individual; however …

Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …

Bone fragility has been recognized as a complication of diabetes, both type 1 diabetes (T1D)
and type 2 diabetes (T2D), whereas the relationship between prediabetes and fracture risk …

A complex interplay of genetic, environmental, hormonal, and behavioral factors affect
skeletal development, several of which are associated with childhood fractures. Given the …

The number of mature osteoblasts and marrow adipocytes in bone is influenced by the
differentiation of the common mesenchymal progenitor cell towards one phenotype and …

Osteocalcin is a bone matrix protein that has been associated with several hormonal actions
on energy and glucose metabolism. Animal and experimental models have shown that …

Historically, obesity was thought to be advantageous for maintaining healthy bones due to
the greater bone mineral density observed in overweight individuals. However, recent …

The protective effect of total fat mass on bone mineral density (BMD) has been challenged
with studies showing no or negative association after adjusting for weight. Subsequently …