A single family of proteases, the caspases, has long been considered the pivotal
executioner of all programmed cell death. However, recent findings of evolutionarily …

Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all
current modalities of cancer therapy. A large set of genetic, functional and biochemical …

The plant response to attempted infection by microbial pathogens is often accompanied by
rapid cell death in and around the initial infection site, a reaction known as the …

Tumour necrosis factor-α (TNFα) is a multifunctional cytokine belonging to a family of ligands
with an associated family of receptor proteins. The pleiotropic actions of TNF range from …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we
evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA)(2: 1 oleate …

Abbreviations: Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse;
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …

To identify human proteins that bind to the Smac and caspase-9 binding pocket on the
baculoviral inhibitor of apoptosis protein (IAP) repeat 3 (BIR3) domain of human XIAP, we …

A pilot program was undertaken in immune gene discovery in two sister species of
litopenaeid shrimp, the Pacific white shrimp, Litopenaeus vannamei and the Atlantic white …

Activation of apoptosis pathways is a key mechanism by which cytotoxic drugs kill tumor
cells. Also immunotherapy of tumors requires an apoptosis sensitive phenotype of target …