The transcription factor activator protein-1 (AP-1) consists of a variety of dimers composed of
members of the Jun and Fos families of proteins. However, it is the up-regulation of c-jun that …

Clozapine and haloperidol produce different induction patterns of c-fos expression in the
forebrain, with haloperidol increasing Fos-like immunoreactivity (FLI) in the striatum, nucleus …

Protein kinase C γ (PKCγ), which is concentrated in interneurons of the inner part of lamina II
of the dorsal horn, has been implicated in injury-induced allodynia, a condition wherein pain …

Animal Models of Analgesia Page 1 CHAPTER 1 Animal Models of Analgesia A. TJ0LSEN
and K. HOLE A. Introduction Measurement of pain and analgesia in animals poses a variety of …

The involvement of cAMP-responsive element-binding protein (CREB) signaling in tissue
injury-induced inflammation and hyperalgesia has been characterized by measuring …

Although it has been shown that pro-inflammatory cytokines such as interleukin-1β (IL-1β)
facilitate perception of noxious inputs at the spinal level, the mechanisms have not been …

Activation of cannabinoid CB2 receptors attenuates thermal nociception in untreated
animals while failing to produce centrally mediated effects such as hypothermia and …

Whole-cell patch-clamp recordings were made from substantia gelatinosa (SG) neurons in
thick adult rat transverse spinal cord slices with attached dorsal roots to study changes in …

Peripheral inflammation induces persistent central sensitization characterized by
mechanical allodynia and heat hyperalgesia that are mediated by distinct mechanisms …

We previously reported the anti-hyperalgesia of electroacupuncture (EA) on persistent
inflammatory pain in an unrestrained, unsedated, and conscious rat model. Using this …