Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

Introduction Myocardial infarction (MI) is the leading cause of congestive heart failure and
mortality. Hypoxia is an important trigger in the cardiac remodeling of the myocardium in the …

The long-held belief about adipose tissue was that it was relatively inert in terms of
biological activity. It was believed that its primary role was energy storage; however, that was …

The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be
possible to regenerate injured heart muscle previously thought to be permanently scarred …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

Aims Comparative studies suggest that stem cells committed to a cardiac lineage are more
effective for improving heart function than those featuring an extra-cardiac phenotype. We …

The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy
have been assessed in several clinical trials. These trials can be categorized as those using …

Summary Background Cardiosphere-derived cells (CDCs) reduce scarring after myocardial
infarction, increase viable myocardium, and boost cardiac function in preclinical models. We …