Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design

Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …

Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents

A Borges, MJ Saavedra… - Current medicinal …, 2015 - ingentaconnect.com
Antimicrobial resistance is one of the most serious public health problems. This is of
particular concern when bacteria become resistant to various antimicrobial agents …

Antibacterial and antifungal terpenes from the medicinal angiosperms of Asia and the Pacific: Haystacks and gold needles

C Wiart, G Kathirvalu, CS Raju, V Nissapatorn… - Molecules, 2023 - mdpi.com
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the
Pacific with antibacterial and/or antifungal activities and analyses their distribution …

Design, synthesis, and biological activities of aromatic gossypol Schiff base derivatives

L Li, Z Li, K Wang, S Zhao, J Feng, J Li… - Journal of agricultural …, 2014 - ACS Publications
A series of aromatic gossypol Schiff bases have been successfully synthesized via a
feasible chemical modification. The antiviral activity against tobacco mosaic virus (TMV) of …

Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa …

MP Celorio-Mancera, SJ Ahn, H Vogel, DG Heckel - BMC genomics, 2011 - Springer
Background Hormesis is a biphasic biological response characterized by the stimulatory
effect at relatively low amounts of chemical compounds which are otherwise detrimental at …

Ethnobotanical and antimicrobial activities of the Gossypium (Cotton) genus: A review

LF De Lima, JO de Oliveira, JNP Carneiro… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance The Malvaceae family, an important group of
plants that have the Gossypium (cotton) genus has been used in folk medicine to treat …

Recent advances in gossypol derivatives and analogs: a chemistry and biology view

Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …

[HTML][HTML] Gossypol detoxification in the rumen and Helicoverpa armigera larvae: A review

WK Wang, HJ Yang, YL Wang, KL Yang, LS Jiang… - Animal Nutrition, 2021 - Elsevier
Gossypol, a phenolic compound found in the cotton plant, is widely distributed in cottonseed
by-products. Although ruminant animals are believed to be more tolerant of gossypol toxicity …

Grafting‐induced seed gossypol levels by demethylation of (+)‐delta‐cadinene synthase genes in upland cotton

M Karaca, AG Ince - Plant Breeding, 2023 - Wiley Online Library
Two‐year‐grafting experiments within and between Gossypium barbadense and Gossypium
hirsutum accessions were conducted to study the source, transfer, and alteration of gossypol …

Cotton roots are the major source of gossypol biosynthesis and accumulation

T Zhao, Q Xie, C Li, C Li, L Mei, JZ Yu, J Chen, S Zhu - BMC plant biology, 2020 - Springer
Background Gossypol is a specific secondary metabolite in Gossypium species. It not only
plays a critical role in development and self-protection of cotton plants, but also can be used …