Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child

M Franzago, F Fraticelli, L Stuppia, E Vitacolonna - Epigenetics, 2019 - Taylor & Francis
ABSTRACT Gestational Diabetes Mellitus (GDM) is the most common metabolic condition
during pregnancy and may result in short-and long-term complications for both mother and …

[HTML][HTML] Epigenetic programming and fetal metabolic programming

Z Zhu, F Cao, X Li - Frontiers in endocrinology, 2019 - frontiersin.org
Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

[HTML][HTML] Genes and diet in the prevention of chronic diseases in future generations

M Franzago, D Santurbano, E Vitacolonna… - International journal of …, 2020 - mdpi.com
Nutrition is a modifiable key factor that is able to interact with both the genome and
epigenome to influence human health and fertility. In particular, specific genetic variants can …

Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology

PP Priyanka, S Yenugu - Reproductive Sciences, 2021 - Springer
The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

[HTML][HTML] Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age

A Taschereau, K Thibeault, C Allard… - Clinical …, 2023 - Springer
Background In utero exposure to maternal hyperglycemia has been associated with an
increased risk for the development of chronic diseases in later life. These predispositions …

Risks of overweight in the offspring of women with gestational diabetes at different developmental stages: A meta‐analysis with more than half a million offspring

M Gao, S Cao, N Li, J Liu, Y Lyu, J Li… - Obesity Reviews, 2022 - Wiley Online Library
We conducted a meta‐analysis to evaluate the association of maternal gestational diabetes
mellitus (GDM) and offspring overweight from birth to adulthood, and to assess the effects of …

Diabetes in pregnancy and epigenetic mechanisms—how the first 9 months from conception might affect the child's epigenome and later risk of disease

L Hjort, B Novakovic, LG Grunnet… - The Lancet Diabetes & …, 2019 - thelancet.com
Diabetes in pregnancy is not only associated with increased risk of pregnancy complications
and subsequent maternal metabolic disease, but also increases the risk of long-term …

Placental fatty acid transfer

RM Lewis, C Wadsack, G Desoye - Current Opinion in Clinical …, 2018 - journals.lww.com
Placental lipid metabolism is likely to be a determinant of placental transfer of fatty acids to
the fetus. Maternal conditions, such as obesity, have now been shown to regulate placental …

Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus

W Zhu, Y Shen, J Liu, X Fei, Z Zhang… - Journal of Cellular …, 2020 - Wiley Online Library
This study aimed to identify epigenetic alternations of microRNAs and DNA methylation for
gestational diabetes mellitus (GDM) diagnosis and treatment using in silico approach. Data …

Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps

L Hjort, B Novakovic, S Cvitic, R Saffery, P Damm… - Epigenetics, 2022 - Taylor & Francis
Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …