Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Hypoxia is known to be detrimental in cancer and contributes to its development. In this
work, we present an approach to fate-map hypoxic cells in vivo in order to determine their …

In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic
adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a …

Increased glucose consumption distinguishes cancer cells from normal cells and is known
as the" Warburg effect" because of increased glycolysis. Lactate dehydrogenase A (LDHA) …

Fetal life evolves in a hypoxic environment. Changes in the oxygen content in utero caused
by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the …

The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …

Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types
self-patterning into a polarized, laminated architecture. In static cultures, organoid …

Since 1991, the NAD (P) H-aided conversion of resazurin to fluorescent resorufin has been
widely used to measure viability based on the metabolic activity in mammalian cell culture …

Skeletal muscle-tissue engineering can be applied to produce cell-based meat for human
consumption, but growth parameters need to be optimized for efficient production and …