In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

Capsaicin, the pungent alkaloid of red pepper (Capsicum annuum) has been extensively
studied for its biological effects which are of pharmacological relevance. These include …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

The peripheral nervous and immune systems are traditionally thought of as serving separate
functions. The line between them is, however, becoming increasingly blurred by new …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory
desmoplastic response. The PDAC microenvironment is complex, containing both pro-and …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Tissue damage evokes an inflammatory response that promotes the removal of harmful
stimuli, tissue repair, and protective behaviors to prevent further damage and encourage …