The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …

The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB
proteins have emerged as critical factors that regulate the lineage commitment …

T cell identity is established during thymic development, but how it is maintained in the
periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors …

A contribution of epigenetic modifications to B cell tolerance has been proposed but not
directly tested. Here we report that deficiency of ten–eleven translocation (Tet) DNA …

Establishing gene regulatory networks during differentiation or reprogramming requires
master or pioneer transcription factors (TFs) such as PU. 1, a prototype master TF of …

In order to support bone marrow regeneration after myeloablation, hematopoietic stem cells
(HSCs) actively divide to provide both stem and progenitor cells. However, the mechanisms …

PAX5, a member of the Paired Box (PAX) transcription factor family, is an essential factor for
B-lineage identity during lymphoid differentiation. Mechanistically, PAX5 controls gene …

B cell development is often depicted as a linear process initiating in the fetus and continuing
postnatally. Using a PU. 1 hypomorphic mouse model, we found that B-1 and B-2 …

Pioneer factors are proteins that can recognize their target sites in barely accessible
chromatin and initiate a cascade of events that allows for later transcriptional activation of …