The effective size of a population, N e, determines the rate of change in the composition of a
population caused by genetic drift, which is the random sampling of genetic variants in a …

Differences in transcription factor binding can contribute to organismal evolution by altering
downstream gene expression programmes. Genome-wide studies in Drosophila …

Neanderthals are the extinct hominid group most closely related to contemporary humans,
so their genome offers a unique opportunity to identify genetic changes specific to …

We describe a genetic variation map for the chicken genome containing 2.8 million single-
nucleotide polymorphisms (SNPs). This map is based on a comparison of the sequences of …

Adaptive evolution is shaped by the interaction of population genetics, natural selection and
underlying network and biochemical constraints. Variation created by mutation, the raw …

How populations diverge and give rise to distinct species remains a fundamental question in
evolutionary biology, with important implications for a wide range of fields, from conservation …

Ancestry and Disease in the Age of Genomic Medicine | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Frequent positive selection is a hallmark of genes involved in the adaptive immune system
of vertebrates, but the incidence of positive selection for genes underlying innate immunity in …

Ecotilling was used as a simple nucleotide polymorphism (SNP) discovery tool to examine
DNA variation in natural populations of the western black cottonwood, Populus trichocarpa …

Genetic and fossil evidence supports a single, recent (< 200,000 yr) origin of modern Homo
sapiens in Africa, followed by later population divergence and dispersal across the globe …