This Perspective presents a review of our work and that of others in the highly controversial
topic of the coupling of protein dynamics to reaction in enzymes. We have been involved in …

Direct biocatalytic processes for CO2 capture and transformation in value-added chemicals
may be considered a useful tool for reducing the concentration of this greenhouse gas in the …

The enzyme soybean lipoxygenase (SLO) provides a prototype for deep tunneling
mechanisms in hydrogen transfer catalysis. This work combines room temperature X-ray …

The greenhouse gas CO 2 is of considerable and particular interest for use as a next
generation feedstock in different types of bioconversions to create valuable products on a …

Proteins are complex, heterogeneous macromolecules that exist as ensembles of
interconverting states on a complex energy landscape. A complete, molecular-level …

Ultrafast two-dimensional infrared (2D-IR) spectroscopy of Escherichia coli Hyd-1 (EcHyd-1)
reveals the structural and dynamic influence of the protein scaffold on the Fe (CO)(CN) 2 unit …

The form of the amide I infrared absorption band provides a sensitive probe of the secondary
structure and dynamics of proteins in the solution phase. However, the frequency …

The pressure to optimize enzymatic rate accelerations has driven the evolution of the
induced-fit mechanism for enzyme catalysts where the binding interactions of nonreacting …

It has recently frequently been found that the kinetic isotope effect (KIE) is independent of
temperature (T) in H-tunneling reactions in enzymes but becomes dependent on T in their …

Protein structural effects on the temperature (T) dependence of kinetic isotope effects (KIEs)
in H-tunneling reactions have recently been used to discuss about the role of enzyme …