Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging
brain and aging-dependent disorders such as neurodegenerative diseases. There is an …

In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …

Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain
and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme …