[HTML][HTML] Recent developments in lactose blend formulations for carrier-based dry powder inhalation

GA Hebbink, M Jaspers, HJW Peters… - Advanced Drug Delivery …, 2022 - Elsevier
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI)
formulations. Numerous inhalation therapies have been developed using lactose as a …

A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols

S Yaqoubi, HK Chan, A Nokhodchi… - International Journal of …, 2021 - Elsevier
Dry powder inhalers (DPI) are widely used systems for pulmonary delivery of therapeutics.
The inhalation performance of DPIs is influenced by formulation features, inhaler device and …

[HTML][HTML] Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance

S Radivojev, G Luschin-Ebengreuth, JT Pinto… - International Journal of …, 2021 - Elsevier
Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a
preferred route for the treatment of various diseases. Yet, the field of inhalation …

Elucidation of the effect of added fines on the performance of dry powder inhalation formulations

M Stankovic-Brandl, S Radivojev, P Sailer… - International Journal of …, 2022 - Elsevier
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic
fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is …

[HTML][HTML] Understanding carrier performance in low-dose dry powder inhalation: An in vitro–in silico approach

JT Pinto, I Cachola, J F. Pinto, A Paudel - Pharmaceutics, 2021 - mdpi.com
The use of physiologically based pharmacokinetic (PBPK) models to support drug product
development has become increasingly popular. The in vitro characterization of the materials …

[HTML][HTML] Effects of particle formation behavior on the properties of fish oil microcapsules fabricated using a micro-fluidic jet spray dryer

X Xiong, S Zhang, N Fu, H Lei, WD Wu… - International Journal of …, 2021 - degruyter.com
Fish oil was encapsulated with whey protein isolate (WPI) as wall material using a Micro-
Fluidic Jet Spray Dryer. The effects of core/wall material ratio, drying temperature and total …

[PDF][PDF] Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach. Pharmaceutics 2021, 13, 297

JT Pinto, I Cachola, JF Pinto, A Paudel - 2021 - pharmaexcipients.com
The use of physiologically based pharmacokinetic (PBPK) models to support drug product
development has become increasingly popular. The in vitro characterization of the materials …

[PDF][PDF] Application of Quality by Design (QbD) in the Development of Dry Powder Inhalers··········

ZH DONG, WU WZ - cjph.com.cn
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·专论与综述(Perspectives & Review)· 质量源于设计(QbD)在干粉吸入剂开发中的应用·································董子豪 …