A microRNA in a multiple-turnover RNAi enzyme complex
G Hutvagner, PD Zamore - Science, 2002 - science.org
In animals, the double-stranded RNA-specific endonuclease Dicer produces two classes of
functionally distinct, tiny RNAs: microRNAs (miRNAs) and small interfering RNAs (siRNAs) …
functionally distinct, tiny RNAs: microRNAs (miRNAs) and small interfering RNAs (siRNAs) …
[HTML][HTML] Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
A Grishok, AE Pasquinelli, D Conte, N Li, S Parrish… - Cell, 2001 - cell.com
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves
the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis …
the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis …
Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
EC Lai - Nature genetics, 2002 - nature.com
Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly …
generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly …
[HTML][HTML] Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal …
Abstract Background The microRNAs (miRNAs) are an extensive class of small noncoding
RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In …
RNAs (18 to 25 nucleotides) with probable roles in the regulation of gene expression. In …
Non–coding RNA genes and the modern RNA world
SR Eddy - Nature Reviews Genetics, 2001 - nature.com
Non-coding RNA (ncRNA) genes produce functional RNA molecules rather than encoding
proteins. However, almost all means of gene identification assume that genes encode …
proteins. However, almost all means of gene identification assume that genes encode …
Specificity of microRNA target selection in translational repression
JG Doench, PA Sharp - Genes & development, 2004 - genesdev.cshlp.org
MicroRNAs (miRNAs) are a class of noncoding RNAs found in organisms as evolutionarily
distant as plants and mammals, yet most of the mRNAs they regulate are unknown. Here we …
distant as plants and mammals, yet most of the mRNAs they regulate are unknown. Here we …
Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA
Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with
messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also …
messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also …
Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
We propose that the microRNA milieu, unique to each cell type, productively dampens the
expression of thousands of mRNAs and provides important context for the evolution of all …
expression of thousands of mRNAs and provides important context for the evolution of all …
[HTML][HTML] Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Y Zhao, JF Ransom, A Li, V Vedantham, M von Drehle… - Cell, 2007 - cell.com
MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …
the expression of proteins generated from messenger RNA transcripts. The in vivo …
Selective blockade of microRNA processing by Lin28
SR Viswanathan, GQ Daley, RI Gregory - Science, 2008 - science.org
MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA
expression has been observed in human malignancies. Recent evidence suggests that the …
expression has been observed in human malignancies. Recent evidence suggests that the …