Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …

Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue
repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed …

LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …

MicroRNAs (miRNAs) are an abundant class of tiny RNAs thought to regulate the expression
of protein-coding genes in plants and animals. In the present study, we describe a …

MicroRNAs (miRNAs) are∼ 22 nucleotide RNAs that negatively regulate the expression of
protein-coding genes. In a present model of miRNA function in animals, miRNAs that form …

Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …

MicroRNAs (miRNAs) are ubiquitous regulators of eukaryotic gene expression. In addition to
repressing translation, miRNAs can down-regulate the concentration of mRNAs that contain …

The canonical microRNA (miRNA) pathway converts primary hairpin precursor transcripts
into∼ 22 nucleotide regulatory RNAs via consecutive cleavages by two RNase III enzymes …

Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic
development and physiology. Amidst an extensive regulatory web that is predicted to involve …

Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several
properties, including a marked reduction in their self-renewal activity. We now show that the …