[HTML][HTML] Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
In Drosophila, two features of small interfering RNA (siRNA) structure—5′ phosphates and
3′ hydroxyls—are reported to be essential for RNA interference (RNAi). Here, we show that …
3′ hydroxyls—are reported to be essential for RNA interference (RNAi). Here, we show that …
[HTML][HTML] Mammalian microRNAs: a small world for fine-tuning gene expression
The basis of eukaryotic complexity is an intricate genetic architecture where parallel systems
are involved in tuning gene expression, via RNA-DNA, RNA-RNA, RNA-protein, and DNA …
are involved in tuning gene expression, via RNA-DNA, RNA-RNA, RNA-protein, and DNA …
A superfamily of proteins that contain the cold-shock domain
PL Graumann, MA Marahiel - Trends in biochemical sciences, 1998 - cell.com
Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial
domain and appear to function as RNA-chaperones. They have been implicated in various …
domain and appear to function as RNA-chaperones. They have been implicated in various …
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans
A Antebi, WH Yeh, D Tait, EM Hedgecock… - Genes & …, 2000 - genesdev.cshlp.org
The daf-12 gene acts at the convergence of pathways regulating larval diapause,
developmental age, and adult longevity in Caenorhabditis elegans. It encodes a nuclear …
developmental age, and adult longevity in Caenorhabditis elegans. It encodes a nuclear …
Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions
D Didiano, O Hobert - Nature structural & molecular biology, 2006 - nature.com
We use Caenorhabditis elegans to test proposed general rules for microRNA (miRNA)-
target interactions. We show that G· U base pairing is tolerated in the'seed'region of the lsy-6 …
target interactions. We show that G· U base pairing is tolerated in the'seed'region of the lsy-6 …
[HTML][HTML] A genome-wide map of conserved microRNA targets in C. elegans
Background Metazoan miRNAs regulate protein-coding genes by binding the 3′ UTR of
cognate mRNAs. Identifying targets for the 115 known C. elegans miRNAs is essential for …
cognate mRNAs. Identifying targets for the 115 known C. elegans miRNAs is essential for …
[HTML][HTML] Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites
EG Moss, L Tang - Developmental biology, 2003 - Elsevier
The heterochronic gene lin-28 is a regulator of developmental timing in the nematode
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …
Detection of 91 potential conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes
MicroRNAs (miRNAs) are an extensive class of tiny RNA molecules that regulate the
expression of target genes by means of complementary base pair interactions. Although the …
expression of target genes by means of complementary base pair interactions. Although the …
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
MicroRNAs (miRNAs) regulate gene expression by guiding Argonaute proteins to specific
target mRNA sequences. Identification of bona fide miRNA target sites in animals is …
target mRNA sequences. Identification of bona fide miRNA target sites in animals is …
MicroRNAs (miRNAs) in neurodegenerative diseases
Aging‐related neurodegenerative diseases (NDs) are the culmination of many different
genetic and environmental influences. Prior studies have shown that RNAs are …
genetic and environmental influences. Prior studies have shown that RNAs are …