[HTML][HTML] Implications of a neuronal receptor family, metabotropic glutamate receptors, in cancer development and progression

K Eddy, MN Eddin, A Fateeva, SVB Pompili, R Shah… - Cells, 2022 - mdpi.com
Cancer is the second leading cause of death, and incidences are increasing globally.
Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the …

[HTML][HTML] Metabolic heterogeneity, plasticity, and adaptation to “glutamine addiction” in cancer cells: the role of glutaminase and the GTωA [glutamine transaminase—ω …

AJL Cooper, T Dorai, JT Pinto, TT Denton - Biology, 2023 - mdpi.com
Simple Summary Many types of cancer cells utilize the common amino acid l-glutamine to
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …

[HTML][HTML] Comprehensive bioinformatics analysis to identify a novel cuproptosis-related prognostic signature and its ceRNA regulatory axis and candidate traditional …

S Wang, N Xing, X Meng, L Xiang… - Frontiers in …, 2022 - frontiersin.org
Lung adenocarcinoma (LUAD) is the most ordinary histological subtype of lung cancer, and
regulatory cell death is an attractive target for cancer therapy. Recent reports suggested that …

[HTML][HTML] Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway

J Cao, X Zhang, P Xu, H Wang, S Wang… - Journal of Experimental …, 2021 - Springer
Background Gastric cancer (GC) is one of the most common malignant tumors worldwide.
Currently, the overall survival rate of GC is still unsatisfactory despite progress in diagnosis …

[HTML][HTML] A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in …

K Koch, R Hartmann, J Tsiampali, C Uhlmann… - Cell death …, 2020 - nature.com
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover.
Limiting the supply of macromolecular precursors by targeting enzymes involved in …

[HTML][HTML] Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes

I Dudka, K Lundquist, P Wikström, A Bergh… - Journal of Translational …, 2023 - Springer
Background Prostate cancer (PC) is a heterogenous multifocal disease ranging from
indolent to lethal states. For improved treatment-stratification, reliable approaches are …

[HTML][HTML] Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with …

C Zhong, K Wu, S Wang, Z Long, T Yang… - Cell Death & …, 2021 - nature.com
Prostate cancer (PCa) is a common high-incidence malignancy in men, some of whom
develop biochemical recurrence (BCR) in the advanced stage. However, there are currently …

Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion

H Mao, Y Wen, Y Yu, H Li, J Wang… - Journal of Materials …, 2023 - pubs.rsc.org
An insufficient intracellular H2O2 level and overexpressed glutathione (GSH) are still the
major challenges for effective chemodynamic therapy (CDT). Inspired by the unique …

[HTML][HTML] Cuproptosis patterns and tumor immune infiltration characterization in colorectal cancer

Y Du, Y Lin, B Wang, Y Li, D Xu, L Gan, X Xiong… - Frontiers in …, 2022 - frontiersin.org
Faced with the high heterogeneity and poor prognosis of colorectal cancer (CRC), this study
sought to find new predictive prognostic strategies to improve the situation. Cuproptosis is a …

[HTML][HTML] Deregulated metabolic pathways in ovarian cancer: cause and consequence

R Murali, V Balasubramaniam, S Srinivas, S Sundaram… - Metabolites, 2023 - mdpi.com
Ovarian cancers are tumors that originate from the different cells of the ovary and account for
almost 4% of all the cancers in women globally. More than 30 types of tumors have been …