[HTML][HTML] Implications of a neuronal receptor family, metabotropic glutamate receptors, in cancer development and progression
Cancer is the second leading cause of death, and incidences are increasing globally.
Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the …
Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the …
[HTML][HTML] Metabolic heterogeneity, plasticity, and adaptation to “glutamine addiction” in cancer cells: the role of glutaminase and the GTωA [glutamine transaminase—ω …
AJL Cooper, T Dorai, JT Pinto, TT Denton - Biology, 2023 - mdpi.com
Simple Summary Many types of cancer cells utilize the common amino acid l-glutamine to
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …
maintain their metabolic demands for energy and the nitrogen required for DNA synthesis …
[HTML][HTML] Comprehensive bioinformatics analysis to identify a novel cuproptosis-related prognostic signature and its ceRNA regulatory axis and candidate traditional …
S Wang, N Xing, X Meng, L Xiang… - Frontiers in …, 2022 - frontiersin.org
Lung adenocarcinoma (LUAD) is the most ordinary histological subtype of lung cancer, and
regulatory cell death is an attractive target for cancer therapy. Recent reports suggested that …
regulatory cell death is an attractive target for cancer therapy. Recent reports suggested that …
[HTML][HTML] Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway
J Cao, X Zhang, P Xu, H Wang, S Wang… - Journal of Experimental …, 2021 - Springer
Background Gastric cancer (GC) is one of the most common malignant tumors worldwide.
Currently, the overall survival rate of GC is still unsatisfactory despite progress in diagnosis …
Currently, the overall survival rate of GC is still unsatisfactory despite progress in diagnosis …
[HTML][HTML] A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in …
K Koch, R Hartmann, J Tsiampali, C Uhlmann… - Cell death …, 2020 - nature.com
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover.
Limiting the supply of macromolecular precursors by targeting enzymes involved in …
Limiting the supply of macromolecular precursors by targeting enzymes involved in …
[HTML][HTML] Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
I Dudka, K Lundquist, P Wikström, A Bergh… - Journal of Translational …, 2023 - Springer
Background Prostate cancer (PC) is a heterogenous multifocal disease ranging from
indolent to lethal states. For improved treatment-stratification, reliable approaches are …
indolent to lethal states. For improved treatment-stratification, reliable approaches are …
[HTML][HTML] Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with …
C Zhong, K Wu, S Wang, Z Long, T Yang… - Cell Death & …, 2021 - nature.com
Prostate cancer (PCa) is a common high-incidence malignancy in men, some of whom
develop biochemical recurrence (BCR) in the advanced stage. However, there are currently …
develop biochemical recurrence (BCR) in the advanced stage. However, there are currently …
Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion
H Mao, Y Wen, Y Yu, H Li, J Wang… - Journal of Materials …, 2023 - pubs.rsc.org
An insufficient intracellular H2O2 level and overexpressed glutathione (GSH) are still the
major challenges for effective chemodynamic therapy (CDT). Inspired by the unique …
major challenges for effective chemodynamic therapy (CDT). Inspired by the unique …
[HTML][HTML] Cuproptosis patterns and tumor immune infiltration characterization in colorectal cancer
Y Du, Y Lin, B Wang, Y Li, D Xu, L Gan, X Xiong… - Frontiers in …, 2022 - frontiersin.org
Faced with the high heterogeneity and poor prognosis of colorectal cancer (CRC), this study
sought to find new predictive prognostic strategies to improve the situation. Cuproptosis is a …
sought to find new predictive prognostic strategies to improve the situation. Cuproptosis is a …
[HTML][HTML] Deregulated metabolic pathways in ovarian cancer: cause and consequence
R Murali, V Balasubramaniam, S Srinivas, S Sundaram… - Metabolites, 2023 - mdpi.com
Ovarian cancers are tumors that originate from the different cells of the ovary and account for
almost 4% of all the cancers in women globally. More than 30 types of tumors have been …
almost 4% of all the cancers in women globally. More than 30 types of tumors have been …