The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …

Malonyl-CoA is an important central metabolite serving as the basic building block for the
microbial synthesis of many pharmaceutically interesting polyketides, but also fatty acid …

Corynebacterium glutamicum is a promising host for production of valuable polyketides.
Propionate addition, a strategy known to increase polyketide production by increasing …

Extensive knowledge and methodological expertise on the bacterial cell biology have been
accumulated over the last decades and bacterial cells have now become an integral part of …

Microbial synthesis of nutraceutically and pharmaceutically interesting plant polyphenols
represents a more environmentally friendly alternative to chemical synthesis or plant …

The textile industry has caused severe water pollution by using many toxic chemicals for
producing fabric dyes. In response to this problem, indigoidine has attracted attention as an …

As a robust, fast growing and genetically tractable organism, the budding yeast
Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its …

Abstract Background The phenylbutanoid 4-(4-hydroxyphenyl) butan-2-one, commonly
known as raspberry ketone, is responsible for the typical scent and flavor of ripe raspberries …

Background Thioesters of coenzyme A participate in 5% of all enzymatic reactions. In
microbial cell factories, they function as building blocks for products of recognized …

Highlights•Semisynthesis and mutasynthesis provide access to many approved
drugs.•Semisynthesis takes advantage of precursor molecules made with engineered …