Muscular dystrophies are primary diseases of muscle due to mutations in more than 40
genes, which result in dystrophic changes on muscle biopsy. Now that most of the genes …

The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

Biochemical and biophysical cues directly affect cell morphology, adhesion, proliferation,
and phenotype, as well as differentiation; thus, they have been commonly utilized for …

Lung adenocarcinoma (LUAD) is the main subtype of lung cancer. In this study, we found
that RBP Mex3a was significantly upregulated in LUAD tissues and elevated Mex3a …

Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally
complex genes. Targeting compensatory modifier genes could be beneficial to improve …

Mutations in the LAMA2 gene affect the production of the α2 subunit of laminin-211 (=
merosin) and result in either partial or complete laminin-211 deficiency. Complete merosin …

Pediatric neuromuscular diseases encompass all disorders with onset in childhood and
where the primary area of pathology is in the peripheral nervous system. These conditions …

Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

The glomerular basement membrane (GBM) is an important component of the kidney's
glomerular filtration barrier. Like all basement membranes, the GBM contains type IV …

Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of
individuals aged over 60 years. While rodents are widely-used model organisms, which …