Nrf2/HO‐1, NF‐κB and PI3K/Akt signalling pathways decipher the therapeutic mechanism of pitavastatin in early phase liver fibrosis in rats
Liver fibrosis is a common chronic hepatic disease. This study aimed to investigate the effect
of pitavastatin (Pit) against thioacetamide (TAA)‐induced liver fibrosis. Rats were divided …
of pitavastatin (Pit) against thioacetamide (TAA)‐induced liver fibrosis. Rats were divided …
Renoprotective Effect of Pitavastatin against TAA‐Induced Renal Injury: Involvement of the miR‐93/PTEN/AKT/mTOR Pathway
MA Elbaset, BMSA Mohamed… - Advances in …, 2024 - Wiley Online Library
This research investigated if pitavastatin (Pita) might protect rats' kidneys against
thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost …
thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost …
[HTML][HTML] Human tendon-on-a-chip for modeling vascular inflammatory fibrosis
Understanding vascular inflammation and myofibroblast crosstalk is critical to developing
therapies for fibrotic diseases. Here we report the development of a novel human Tendon-on …
therapies for fibrotic diseases. Here we report the development of a novel human Tendon-on …
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression
I Fabregat, J Amengual, J Vaquero… - 2024 - researchsquare.com
Iron overload and cellular senescence have been implicated in liver fibrosis, but their
possible mechanistic connection has not been explored. To address this, we have …
possible mechanistic connection has not been explored. To address this, we have …
Human tendon-on-a-chip for modeling vascular inflammatory fibrosis
Understanding vascular inflammation and myofibroblast crosstalk is critical to developing
therapies for fibrotic diseases. Here we report the development of a novel human Tendon-on …
therapies for fibrotic diseases. Here we report the development of a novel human Tendon-on …