RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Nanopore RNA sequencing shows promise as a method for discriminating and identifying
different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing …

ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal …