Human dyskerin is an evolutively conserved protein that participates in diverse nuclear
complexes: the H/ACA snoRNPs, that control ribosome biogenesis, RNA pseudouridylation …

Pituitary tumors represent the most common intracranial neoplasms accompanying serious
morbidity through mass effects and inappropriate secretion of pituitary hormones …

Abstract H/ACA ribonucleoproteins (H/ACA RNPs) are responsible for introducing many
pseudouridines into RNAs, but are also involved in other cellular functions. Utilizing a …

Cellular RNAs, both coding and noncoding are adorned by> 100 chemical modifications,
which impact various facets of RNA metabolism and gene expression. Very often …

The RNA-binding protein dyskerin, encoded by the DKC1 gene, functions as a core
component of the telomerase holoenzyme as well as ribonuclear protein complexes …

Ovarian granulosa cell tumors (GCTs) originate from granulosa cells (GCs) and represent
the most common sex cord-stromal tumor in humans. However, the developmental …

Dyskerin is a nucleolar protein encoded by the DKC1 gene that (i) stabilizes the RNA
component of the telomerase complex, and (ii) drives the site-specific pseudouridilation of …

Therapeutic resistance is the major contributor to the poor prognosis of and low survival from
pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions …

Background Dihydrouridine (D) is one of the most significant uridine modifications that have
a prominent occurrence in eukaryotes. The folding and conformational flexibility of transfer …

The central dogma of molecular biology statically says that the information flows from DNA to
messenger RNA to protein. But the recent advances in mass spectrometry and high …