The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …

A variety of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis
of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By …

Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis, indicating a
requirement for NOTCH during maintenance of joint cartilage. However, NOTCH signaling …

Abstract Background Systemic sclerosis (SSc), a multi-organ disorder, is characterized by
vascular abnormalities, dysregulation of the immune system, and fibrosis. The mechanisms …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction
(WTD) in rheumatoid arthritis (RA) through network pharmacology prediction and …

Dental pulp-derived stromal cells (DPSCs) are a crucial cell population for maintaining the
tissue integrity of the pulp-dentin complex. The oxytocin receptor (OXTR), a member of the G …

Proteinases are enzymes with established roles in physiological and pathological processes
such as digestion and the homeostasis, destruction and repair of tissues. Over the past few …

Macrophages have emerged as a key component of the innate immune system that
emigrates to peripheral tissues during gestation and in the adult organism. Their complex …