The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

The growing incidence of microorganisms that resist antimicrobials is a constant concern for
the scientific community, while the development of new antimicrobials from new chemical …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Alkaloids are important chemical compounds that serve as a rich reservoir for drug
discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and …

Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …

A critical question in natural product-based drug discovery is how to translate the product
into drug-like molecules with optimal pharmacological properties. The generation of natural …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

Computer-aided drug design plays a vital role in drug discovery and development and has
become an indispensable tool in the pharmaceutical industry. Computational medicinal …