Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Background Recent clinical data support the utility/superiority of a new AKI biomarker
(“NephroCheck”), the arithmetic product of urinary TIMP× IGFBP7 concentrations. However …

NephroCheck® is the commercial name of a combined product of two urinary biomarkers,
tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding …

Cancer is the second most fatal disease worldwide, with colon cancer being the third most
prevalent and fatal form of cancer in several Western countries. The risk of acquisition of …

The complexity and application range of interventional and diagnostic procedures using
contrast media (CM) have recently increased. This allows more patients to undergo …

Abstract Carbon tetrachloride (CCl4)‐induced liver injury is predominantly caused by free
radicals, in which mitochondrial function of hepatocytes is impaired, accompanying with the …

Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous
proteins that primarily function to inhibit the activities of proteases such as the matrix …

Background: Existing research shows that p-coumaric acid (p-CA) can inhibit the
proliferation of a variety of tumor cells in vitro. However, there are no reports on the anti …