Oxidative stress in obstructive sleep apnea and intermittent hypoxia–revisited–the bad ugly and good: implications to the heart and brain
L Lavie - Sleep medicine reviews, 2015 - Elsevier
Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is linked with
increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative …
increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative …
Therapeutic potential of intermittent hypoxia: a matter of dose
A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …
triggers a bewildering array of both detrimental and beneficial effects in multiple …
[HTML][HTML] Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
D Wakhloo, F Scharkowski, Y Curto… - Nature …, 2020 - nature.com
Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian
brain. In clinical settings, recombinant EPO treatment has revealed a remarkable …
brain. In clinical settings, recombinant EPO treatment has revealed a remarkable …
Sleep apnoea and the brain: a complex relationship
I Rosenzweig, M Glasser, D Polsek… - The Lancet …, 2015 - thelancet.com
Intermittent hypoxia, reoxygenation, and hypercapnia or hypocapnia occur in both adults
and children during untreated apnoea and hypopnoea, along with changes in cerebral …
and children during untreated apnoea and hypopnoea, along with changes in cerebral …
Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …
strategy to improve respiratory and non-respiratory motor function in people with …
[HTML][HTML] Physiological and biological responses to short-term intermittent hypobaric hypoxia exposure: from sports and mountain medicine to new biomedical …
G Viscor, JR Torrella, L Corral, A Ricart… - Frontiers in …, 2018 - frontiersin.org
In recent years, the altitude acclimatization responses elicited by short-term intermittent
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …
Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach
E Sforza, F Roche - Hypoxia, 2016 - Taylor & Francis
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent
risk factor for cardiovascular consequences, such as systemic arterial hypertension …
risk factor for cardiovascular consequences, such as systemic arterial hypertension …
Intermittent hypoxia and neurorehabilitation
In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …
Pathophysiology of human ventilatory control
JA Dempsey, CA Smith - European Respiratory Journal, 2014 - Eur Respiratory Soc
We review the substantial recent progress made in understanding the underlying
mechanisms controlling breathing and the applicability of these findings to selected human …
mechanisms controlling breathing and the applicability of these findings to selected human …
The polymorphic and contradictory aspects of intermittent hypoxia
I Almendros, Y Wang, D Gozal - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a
surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in …
surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in …