Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …

We perform a large-scale meta-analysis of 51 peer-reviewed 3xTg-AD mouse publications
to compare Alzheimer's disease (AD) quantitative clinical outcome measures, including …

Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
memory loss and disordered cognition. Women have a higher AD incidence than men …

Accumulating studies affirm the effects of age-related endocrine dysfunction on cognitive
decline and increasing risk of neurodegenerative diseases. It is well known that estrogens …

Clinical studies and experimental data together support a role for pituitary gonadotropins,
including luteinizing hormone (LH), otherwise considered solely as fertility hormones, in age …

Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual
maturation and regulation of the reproductive cycle in the human organism. GnRH interacts …

Female mammals undergo natural fluctuations in sex steroid hormone levels throughout life.
These fluctuations span from early development, to cyclic changes associated with the …

This article is part of a Special Issue “SBN 2014”. Hormonal dysfunction due to aging,
especially during menopause, plays a substantial role in cognitive decline as well as the …

Alzheimer's disease (AD) pathogenesis is a multifactorial process that involves numerous
pathways within the central nervous system. Thus, interventions that interact with several …