While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

Objective To study antibody‐independent contributions of B cells to inflammatory disease
activity, and the immune consequences of B‐cell depletion with rituximab, in patients with …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) in which the immune system damages the protective insulation surrounding the nerve …

Experimental autoimmune encephalomyelitis (EAE) is still the most widely accepted animal
model of multiple sclerosis (MS). Different types of EAE have been developed in order to …

Recent studies demonstrated the presence of autoantibodies to native myelin
oligodendrocyte glycoprotein (MOG) in juvenile patients with acute disseminated …

Objective To study the humoral immune response directed at myelin oligodendrocyte
glycoprotein (MOG) in pediatric patients with isolated and recurrent optic neuritis (ON) …

Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …

Immune reactions inside the central nervous system are finely regulated, thanks to the
presence of several checkpoints that have the fundamental purpose to preserve this fragile …