The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …

Classic embryological studies have successfully applied genetics and cell biology principles
to understand embryonic development. However, it remains unresolved how mechanics, as …

The world's most revered and eloquent interpreter of evolutionary ideas offers here a work of
explanatory force unprecedented in our time—a landmark publication, both for its historical …

Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

The simple yet powerful technique of induced pluripotency may eventually supply a wide
range of differentiated cells for cell therapy and drug development. However, making the …

The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor
suppressor protein that is defective in basal cell nevus syndrome (BCNS). Functions of PTC …

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics,
including their pseudoepithelial morphology and their ability to divide and differentiate …

The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has
been ongoing controversy regarding the possible adverse effects of glyphosate on the …