The functional unit of the endocrine pancreas is the islet of Langerhans. Islets are nested
within the exocrine tissue of the pancreas and are composed of α-, β-, δ-and γ-cells1. β …

Aniridia is a semidominant disorder in which development of the iris, lens, cornea and retina
is disturbed. The mouse mutation Small eye (Sey), which has been proposed as a model for …

The mammalian telencephalon is considered the most complex of all biological structures. It
comprises a large number of functionally and morphologically distinct types of neurons that …

Although microRNAs (miRNAs) provide a newly recognized level of regulation of gene
expression, the miRNA transcriptome of the retina and the contributions of miRNAs to retinal …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

During early mouse development the homeobox gene Hesx1 is expressed in prospective
forebrain tissue, but later becomes restricted to Rathke's pouch, the primordium of the …

The molecular mechanisms that control regional specification, morphogenesis and
differentiation of the embryonic forebrain are not known, although recently seueral …

We present genetic and biochemical evidence that PAX6 is a key regulator of pancreatic
islet hormone gene transcription and is required for normal islet development. In embryos …

We generated mice with a null mutation of the forebrain-restricted transcription factor BF-1 to
examine its function in brain development. Heterozygous animals have an apparently …

Pax genes encode a family of transcription factors that orchestrate complex processes of
lineage determination in the developing embryo. Their key role is to specify and maintain …