Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

The globally increasing prevalence of obesity is associated with the development of
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …

Sympathetic innervation is essential for the development of functional beige fat that
maintains body temperature and metabolic homeostasis, yet the molecular mechanisms …

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to
contribute to age-related diseases. Although aging-associated immune dysfunction, or …

Objectives Genome-wide association studies (GWAS) have successfully revealed numerous
susceptibility loci for obesity. However, identifying the causal genes, pathways, and …

Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described
in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we …

Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Obesity is characterized by adipose tissue expansion, extracellular matrix remodelling and
unresolved inflammation that contribute to insulin resistance and fibrosis. Adipose tissue …

The Hippo pathway is a central regulator of tissue growth that has been widely studied in
mammalian organ development, regeneration, and cancer biology. Although previous …

Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and
represent a targetable population to lessen obesity-associated health risks. However, ATMs …