[HTML][HTML] The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

[HTML][HTML] Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

[HTML][HTML] METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Y Xu, D Lv, C Yan, H Su, X Zhang, Y Shi, K Ying - Cancer cell international, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) has emerged as a significant regulator of
the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains …

[HTML][HTML] Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

[HTML][HTML] m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

[HTML][HTML] Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

[HTML][HTML] Role of m6A modification in female infertility and reproductive system diseases

J Chen, Y Fang, Y Xu, H Sun - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Gamete abnormalities and reproductive system tumors have become a dominant cause of
infertility, troubling people globally. In recent years, increasing evidence emerged and found …

m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells

M Shen, M Guo, Y Li, Y Wang, Y Qiu, J Shao… - Free Radical Biology …, 2022 - Elsevier
Activation of hepatic stellate cells (HSCs) is a central event in the development of liver
fibrosis, and the elimination of activated HSCs is considered to be an effective anti-fibrotic …

[HTML][HTML] Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application

F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …