Activity-based protein profiling (ABPP) has emerged as a powerful strategy to study the
activity of enzymes in complex proteomes. The aim of ABPP is to selectively visualize only …

The emergence of synthetic glycoconjugates as chemical probes for the detection of
glycosidase enzymes has resulted in the development of a range of useful chemical tools …

Lysosomal degradation of glycosphingolipids is mediated by the consecutive action of
several glycosidases. Malfunctioning of one of these hydrolases can lead to a lysosomal …

Activity‐based protein profiling has emerged as a powerful discovery tool in chemical
biology and medicinal chemistry research. Success of activity‐based protein profiling hinges …

The synthesis and evaluation as activity‐based probes (ABPs) of three configurationally
distinct, fluorescent N‐alkyl cyclophellitol aziridine isosteres for profiling GH1 β‐glucosidase …

The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based
retaining β-glucosidase inhibitors. In this paper we explore the inhibitory potency of a …

The development of renewable biofuels is a global priority, but success will require novel
technologies that greatly improve our understanding of microbial systems biology. An …

Mass cytometry (MC) is a powerful method that combines the cellular resolution of flow
cytometry with the isotopic resolution of inductively coupled plasma mass spectrometry (ICP …

A divergent synthesis to eight d‐xylo‐and l‐arabino‐cyclophellitol and cyclophellitol
aziridine derivatives is described. The syntheses start from d‐xylose and feature asymmetric …

Glycoconjugate analogues in which the sp3‐hybridized C2 position of the carbohydrate
structure (normally bearing a hydroxy group) is converted into a compact sp2‐hybridized …