Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Cell death mechanisms in cerebral ischemia–reperfusion injury

Q Zhang, M Jia, YF Wang, Q Wang, J Wu - Neurochemical research, 2022 - Springer
Ischemic stroke is one of the major causes of morbidity and mortality, affecting millions of
people worldwide. Inevitably, the interruption of cerebral blood supply after ischemia may …

Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis

P Zhou, W Xie, S He, Y Sun, X Meng, G Sun, X Sun - Cells, 2019 - mdpi.com
Panax ginseng and Panax notoginseng, two well-known medical plants with economic
value, have a long history of use for managing various diseases in Asian countries …

[HTML][HTML] New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease

J Wu, Y Yang, Y Wan, J Xia, JF Xu, L Zhang… - Biomedicine & …, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disorder in the elderly
characterized by memory loss and cognitive dysfunction. The pathogenesis of AD is …

[HTML][HTML] Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

K Zhai, H Duan, W Wang, S Zhao, GJ Khan… - … Pharmaceutica Sinica B, 2021 - Elsevier
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as
a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve …

New therapeutic approaches to and mechanisms of ginsenoside Rg1 against neurological diseases

Y Sun, Y Yang, S Liu, S Yang, C Chen, M Lin, Q Zeng… - Cells, 2022 - mdpi.com
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury …

[HTML][HTML] Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy

D Wang, L Lv, Y Xu, K Jiang, F Chen, J Qian… - Biomedicine & …, 2021 - Elsevier
Morbidity and mortality from acute myocardial infarction (AMI) remains substantial although
interventional coronary reperfusion strategies are widely use and successful. MI remains the …

Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice

J Chen, X Zhang, X Liu, C Zhang, W Shang… - European journal of …, 2019 - Elsevier
Angiogenesis plays an important role in the remodeling process of the ischemic brain and
the recovery of neurological function after ischemic stroke. Ginsenoside Rg1 has been …

An Ultrasmall Cu/Cu2O Nanoparticle-Based Diselenide-Bridged Nanoplatform Mediating Reactive Oxygen Species Scavenging and Neuronal Membrane …

J Kong, R Zou, R Chu, N Hu, J Liu, Y Sun, X Ge… - ACS …, 2023 - ACS Publications
Ischemic stroke is one of the major causes of death and disability worldwide, and an
effective and timely treatment of ischemic stroke has been a challenge because of the …