The field of prostate cancer has been the subject of extensive research that has resulted in
important discoveries and shaped our appreciation of this disease and its management …

Prostate cancer is unique among the potentially lethal human malignancies in the wide
discrepancy between the high prevalence of histologic changes recognizable as cancer and …

A case‐control study was performed to estimate the relative risk of developing prostate
cancer for men with a positive family history. Extensive cancer pedigrees were obtained on …

Background In 2002, we reported the initial results of a trial comparing radical prostatectomy
with watchful waiting in the management of early prostate cancer. After three more years of …

Background The benefit of radical prostatectomy in patients with early prostate cancer has
been assessed in only one randomized trial. In 2005, we reported that radical prostatectomy …

ContextAmong men with early prostate cancer, the natural history without initial therapy
determines the potential for survival benefit following radical local treatment. However, little …

Background Radical prostatectomy is widely used in the treatment of early prostate cancer.
The possible survival benefit of this treatment, however, is unclear. We conducted a …

Pathologic evaluation of tumor extent in a radical prostatectomy specimen for prostatic
adenocarcinoma is extremely important in staging and planning further therapy. We studied …

Objective.—To determine the clinical and economic effects of screening for prostate cancer
with prostate-specific antigen (PSA), transrectal ultrasound (TRUS), and digital rectal …

Indications for TRUS are:(a) for diagnosis of nonpalpable cancer, or detection of cancer with
greater accuracy than is possible at present;(b) for guidance of transrectal biopsies of …