Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death
worldwide. In the past decade, there have been improvements in non-drug therapies and …

Simple Summary Aberrant Wnt/β-catenin signaling has been reported to play crucial role in
pathogenesis of hepatocellular carcinoma (HCC). In this review, we focus on the regulatory …

Highlights•Poly [ADP-ribose] polymerase 1 (PARP1) is a promising cancer therapeutic target
for synergistic combinations of drugs.•PARP1 has a direct role in DNA repair for cancer …

Simple Summary Human primary liver cancers have a poor prognosis. At present, there are
limited treatment alternatives, and to understand the molecular aspects of liver …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Zinc finger E-box-binding homeobox 1 (ZEB1), a functional protein of zinc finger family, was
aberrant expressed in many kinds of liver disease including hepatic fibrosis and Hepatitis C …

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver
disease, the long-term loss of hepatocytes often leads to adverse consequences such as …

Abstract Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) are two homologous proteins that
are gaining increasing importance due to their implication in multiple pathways and …

Gastric cancer is a common malignancy worldwide. However, the molecular mechanisms
underlying this malignancy remain unclear and there are a lack of effective drugs. The …