[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

BA Tayeb, IY Kusuma, AAM Osman… - Journal of Integrative …, 2024 - Elsevier
Background The field of personalized medicine has gained increasing attention in cancer
care, with the aim of tailoring treatment strategies to individual patients for improved …

Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway

D Fei, F Wang, Y Wang, J Chen, S Chen, L Fan… - Molecular Cancer, 2024 - Springer
Circular RNA (circRNA) is thought to mediate the occurrence and development of human
cancer and usually acts as a tiny RNA (miRNA) sponge to regulate downstream gene …

[PDF][PDF] Exosomes derived from hypoxic glioma cells reduce the sensitivity of glioma cells to temozolomide through carrying miR-106a-5p

P Wu, J Guo, H Yang, D Yuan, C Wang… - Drug design …, 2022 - Taylor & Francis
Background Hypoxia is a frequent feature of solid tumors which significantly affects the
efficacy of treatments such as chemotherapy. In addition, exosomes from hypoxic cancer …

Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer

D Cui, Z Luo, X Liu, X Chen, Q Zhang… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives To explore the underlying mechanism of total flavonoids of Litchi seed (TFLS) in
treating prostate cancer (PCa). Methods Cell Counting Kit-8 (CCK-8), EdU incorporation …

CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma

K Tang, X Li, J Mo, Y Chen, C Huang, T Li, T Luo… - Scientific Reports, 2023 - nature.com
The prevalence and mortality of hepatocellular carcinoma (HCC) are still increasing. This
study aimed to identify potential therapeutic targets related to patient prognosis. Data were …

Exploring the anti-hepatocellular carcinoma effects of Xianglian Pill: Integrating network pharmacology and RNA sequencing via in silico and in vitro studies

J Huang, R Shi, F Chen, HY Tan, J Zheng, N Wang… - Phytomedicine, 2024 - Elsevier
Background Liver cancer represents a most common and fatal cancer worldwide. Xianglian
Pill (XLP) is an herbal formula holding great promise in clearing heat for treating diseases in …

Design, Synthesis, Antitumor Activity and NMR‐Based Metabolomics of Novel Amino Substituted Tetracyclic Imidazo[4,5‐b]Pyridine Derivatives

N Perin, B Lončar, M Kadić, M Kralj… - …, 2024 - Wiley Online Library
Abstract Newly prepared tetracyclic imidazo [4, 5‐b] pyridine derivatives were synthesized to
study their antiproliferative activity against human cancer cells. Additionally, the structure …

Celestial Insights: Unraveling the Role of miR-3682-3p in Hepatocellular Carcinoma

PD Miao, Y Li, YD Jiang - Clinical and Translational …, 2024 - journals.lww.com
Hepatocellular carcinoma (HCC) remains a formidable oncological challenge, calling for
innovative therapeutic strategies to improve patient outcomes. MicroRNAs have emerged as …

Systems Pharmacology Strategy for the Investigation of Action Mechanisms of Qin Herb Libanotis Buchtormensis (Fisch.) DC. in Bone Diseases

R Feng, L Wang, H Chai, J Jiao… - … Metabolic & Immune …, 2024 - ingentaconnect.com
Introduction: Qin medicines are medicinal plants growing in habitat around the peak of
Qinling Mountain. Their unique curative effects on bone metabolic diseases and pain …