Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …

Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative
diseases, although the contributions of specific glycan structures to emotion and cognitive …

Tumor metastasis involves cancer cell invasion across basement membranes and interstitial
tissues. The initial invasion step consists of adherence of the tumor cell to the extracellular …

Sulfated glycosaminoglycan (GAG) chains are a class of long linear polysaccharides that
are covalently attached to multiple core proteins to form proteoglycans (PGs). PGs are major …

Recently, we demonstrated that FAM20B is a kinase that phosphorylates the xylose (Xyl)
residue in the glycosaminoglycan-protein linkage region of proteoglycans. The …

Joint and skeletal development is highly regulated by extracellular matrix (ECM)
proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class …

Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …

Raine syndrome, a lethal osteosclerotic bone dysplasia in humans, is caused by loss-of-
function mutations in FAM20C; however, Fam20c deficiency in mice does not recapitulate …

Hyperelongation of glycosaminoglycan chains on proteoglycans facilitates increased
lipoprotein binding in the blood vessel wall and the development of atherosclerosis …