Biosynthesis and function of chondroitin sulfate
T Mikami, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …
and extracellular components that form regulatory milieu involving numerous biological and …
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease
A Basu, NG Patel, ED Nicholson… - American Journal of …, 2022 - journals.physiology.org
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …
expressed on the cell surface and in the extracellular matrix of all animal cells. These …
Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memory
H Huang, AM Joffrin, Y Zhao… - Proceedings of the …, 2023 - National Acad Sciences
Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative
diseases, although the contributions of specific glycan structures to emotion and cognitive …
diseases, although the contributions of specific glycan structures to emotion and cognitive …
[HTML][HTML] Chondroitin sulfate–mediated N-cadherin/β-catenin signaling is associated with basal-like breast cancer cell invasion
S Nadanaka, H Kinouchi, H Kitagawa - Journal of Biological Chemistry, 2018 - ASBMB
Tumor metastasis involves cancer cell invasion across basement membranes and interstitial
tissues. The initial invasion step consists of adherence of the tumor cell to the extracellular …
tissues. The initial invasion step consists of adherence of the tumor cell to the extracellular …
Sulfated glycosaminoglycans: their distinct roles in stem cell biology
T Mikami, H Kitagawa - Glycoconjugate Journal, 2017 - Springer
Sulfated glycosaminoglycan (GAG) chains are a class of long linear polysaccharides that
are covalently attached to multiple core proteins to form proteoglycans (PGs). PGs are major …
are covalently attached to multiple core proteins to form proteoglycans (PGs). PGs are major …
[HTML][HTML] Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans
T Koike, T Izumikawa, B Sato, H Kitagawa - Journal of Biological Chemistry, 2014 - ASBMB
Recently, we demonstrated that FAM20B is a kinase that phosphorylates the xylose (Xyl)
residue in the glycosaminoglycan-protein linkage region of proteoglycans. The …
residue in the glycosaminoglycan-protein linkage region of proteoglycans. The …
[HTML][HTML] Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
DG Wilson, K Phamluong, WY Lin, K Barck… - Developmental …, 2012 - Elsevier
Joint and skeletal development is highly regulated by extracellular matrix (ECM)
proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class …
proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class …
Human genetic disorders and knockout mice deficient in glycosaminoglycan
S Mizumoto, S Yamada… - BioMed research …, 2014 - Wiley Online Library
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …
monosaccharides by various glycosyltransferases and maturated by epimerases and …
[HTML][HTML] Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia
T Koike, T Mikami, JI Tamura, H Kitagawa - Nature Communications, 2022 - nature.com
Raine syndrome, a lethal osteosclerotic bone dysplasia in humans, is caused by loss-of-
function mutations in FAM20C; however, Fam20c deficiency in mice does not recapitulate …
function mutations in FAM20C; however, Fam20c deficiency in mice does not recapitulate …
The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
MA Rostam, D Kamato, TJ Piva, W Zheng, PJ Little… - Cellular …, 2016 - Elsevier
Hyperelongation of glycosaminoglycan chains on proteoglycans facilitates increased
lipoprotein binding in the blood vessel wall and the development of atherosclerosis …
lipoprotein binding in the blood vessel wall and the development of atherosclerosis …