Tyrosine kinase inhibitors and immunotherapy updates in neuroendocrine neoplasms

O Mosalem, MB Sonbol, TR Halfdanarson… - Best Practice & Research …, 2023 - Elsevier
Neuroendocrine tumors (NETs) represent a heterogeneous group of malignancies that arise
from neuroendocrine cells dispersed throughout the organs/tissues of the body. Treatment of …

Systemic Therapy for Pancreatic Neuroendocrine Tumors

M Wheless, S Das - Clinical Colorectal Cancer, 2023 - Elsevier
Patients with metastatic or advanced pancreatic neuroendocrine tumors (NETs) carry poorer
prognoses relative to patients with other NETs due to bulkier and often, more proliferative …

Detecting Somatic Mutations for Well-Differentiated Pancreatic Neuroendocrine Tumors in Endoscopic Ultrasound-Guided Fine Needle Aspiration with Next …

EM Ghabi, JR Habib, S Shoucair, AA Javed… - Annals of surgical …, 2023 - Springer
Abstract Background Pancreatic neuroendocrine tumors (PanNETs) exhibit heterogenous
behavior, whereby some small tumors are aggressive with a propensity for metastasis …

Surgical Management and Long-Term Evaluation of Pancreatic Neuroendocrine Tumors

S Ghabra, B Ramamoorthy, SG Andrews… - Surgical …, 2024 - surgical.theclinics.com
Neuroendocrine tumors (NETs) originate from neuroendocrine cells located in different
organs throughout the body, such as the lung, pancreas, and digestive tract. NETs may …

Indications for genetic study in gastro-entero-pancreatic and thoracic neuroendocrine tumors

M Araujo-Castro - Endocrinología, Diabetes y Nutrición (English ed.), 2023 - Elsevier
Abstract Gastro-entero-pancreatic (GEP-NET) and thoracic neuroendocrine tumours (NETs)
are one of the most heritable groups of neoplasms in the body, being multiple endocrine …

Centralization of care for rare genetic syndromes associated with cancer: improving outcomes and advancing research on VHL disease

A Larcher, F Belladelli, F Cei, C Re, I Rowe… - Nature Reviews …, 2024 - nature.com
Abstract Von Hippel–Lindau (VHL) disease is a rare genetic syndrome caused by a
germline pathogenic variant in one VHL allele. Any somatic event disrupting the other allele …

Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation

Z Saleh, MC Moccia, Z Ladd, U Joneja, Y Li… - International Journal of …, 2024 - mdpi.com
Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling
pathways that are crucial for tumor formation and progression. The efficacy of traditional …

Molecular alterations and therapeutic targets in pancreatic neuroendocrine tumors

Y Ma, X Wang, H Zhao, Y Jiao - Journal of Pancreatology, 2023 - journals.lww.com
Human pancreatic neuroendocrine tumors (PanNETs) are a rare, deadly tumor type that is
sporadic or arises in the background of a hereditary syndrome. A critical genetic event in …

Indicaciones de estudio genético en los tumores neuroendocrinos gastro-entero-pancreáticos y torácicos

M Araujo-Castro - Endocrinología, Diabetes y Nutrición, 2023 - Elsevier
Los tumores neuroendocrinos (TNE) gastro-entero-pancreáticos (TNE-GEP) y torácicos son
uno de los grupos de neoplasias más heredables del organismo, siendo el síndrome de …

[HTML][HTML] Transformation of metastatic nonfunctioning pancreatic neuroendocrine tumor into insulinoma—two case reports

LW Wu, SMQ Hussaini, JW Lee, DH Shu… - Annals of Pancreatic …, 2022 - apc.amegroups.org
Background: Pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms that are
characterized by hormonal symptoms. While most PanNETs are nonfunctional, there have …