CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role
in assisting correct folding and functionality of its client proteins in cells. The Hsp90 client …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Malignant transformation and maintenance of the malignant phenotype depends on
oncogenic and non-oncogenic proteins that are essential to mediate oncogene signaling …

Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-
competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been …

Molecular chaperones, as the name suggests, are involved in folding, maintenance,
intracellular transport, and degradation of proteins as well as in facilitating cell signaling …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

Compounds targeting the circadian clock have been identified as potential treatments for
clock-related diseases, including cancer. Our cell-based phenotypic screen revealed …