The dramatic increase of microbial resistances against conventional available antibiotics is
a huge challenge to the effective treatment of infectious disease and thus becoming a …

The need for new antimicrobial therapies is evident, especially to reduce antimicrobial
resistance and minimize deleterious effects on gut microbiota. However, although diverse …

Novel antibacterial therapies are urgently required to tackle the increasing number of
multidrug‐resistant pathogens. Identification of new antimicrobial targets is critical to avoid …

As the global burden of antibiotic resistance continues to grow, creative approaches to
antibiotic discovery are needed to accelerate the development of novel medicines. A rapidly …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

Antibiotics have had a profound impact on human society by enabling the eradication of
otherwise deadly infections. Unfortunately, antibiotic use and overuse has led to the rapid …

Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …

Introduction Pathogen-focused, randomized, controlled trials (PF-RCT) are important in the
fight against carbapenem-resistant (CR) Gram-negative infections. Some recently approved …

The increasing dissemination of multidrug resistant (MDR) bacterial infections endangers
global public health. How to develop effective antibacterial agents against resistant bacteria …