Our understanding about the epidemiological aspects, pathogenesis, molecular diagnosis,
and targeted therapies of neuroendocrine neoplasms (NENs) have drastically advanced in …

Somatostatin (SST) is a small peptide that exerts inhibitory effects on a wide range of
neuroendocrine cells. Due to the fact that somatostatin regulates cell growth and hormone …

Well-differentiated neuroendocrine tumors (NETs) of the stomach and pancreas represent 2
major subtypes of gastrointestinal NETs. Historically, there has been little consensus on the …

Background and purpose Combined mTORC1 inhibition with everolimus (EVE) and
phosphatidylinositol 3-kinase catalytic subunit p110α blockade with alpelisib (ALP) has …

Gastroenteropancreatic neuroendocrine neoplasms are a heterogenous group of rare
neoplasms that are increasingly being discovered, often incidentally, throughout the …

The growing importance of advanced endoscopy in the diagnosis and treatment of
pancreatic neuroendocrine neoplasms (PanNETs) necessitates a comprehensive …

Pancreatic incidentalomas (PIs) represent a clinical entity increasingly recognized due to
advances in and easier access to imaging techniques. By definition, PIs should be detected …

Introduction: Cancer-associated fibroblasts (CAF) have been identified as relevant
contributors to cancer progression and drug resistance in many tumors. Although …

Background/objective Pancreatic neuroendocrine tumors (P-NETs) are highly
heterogeneous with wide spectrum of biological behaviors and growth patterns. Here, we …

Simple Summary Neuroendocrine neoplasia comprise many distinct and rare subtypes of
cancers. Preclinical models are essential for improving understanding of these diseases …