New tumor types are continuously being described with advances in molecular testing and
genomic analysis resulting in better prognostics, new targeted therapy options and improved …

EWSR1-PATZ1 fusions, first described in small round or spindle cell sarcomas (1) have
recently been reported in rare low-and high-grade CNS tumors (1–6). Among the cerebral …

In recently published articles, the superior outcome of infant patients with high-grade
gliomas (HGGs) when compared with older children was demonstrated. Receptor tyrosine …

Gliomas are a diverse group of primary central nervous system tumors with astrocytic,
oligodendroglial, and/or ependymal features and are an important cause of …

Within the past decade, incremental integration of molecular characteristics into the
classification of central nervous system neoplasms increasingly facilitated precise diagnosis …

Significant advances in our understanding of the molecular genetics of pediatric and adult
brain tumors and the resulting rapid expansion of clinical molecular neuropathology have …

Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most
lethal primary malignant tumors in the central nervous system (CNS). Since pediatric-type …

Gliomas are the most common primary central nervous system (CNS) tumors and a major
cause of cancer-related mortality in children (age< 15 years), adolescents and young adults …

Central nervous system (CNS) cancers account for approximately one quarter of all pediatric
tumors and are the leading cause of cancer-related death in children. More than 4,000 brain …

Background: Periodic updates to the World Health Organization (WHO) classification system
for central nervous system (CNS) tumors reflect advances in the pathological diagnosis …