Androgen receptor (AR) is a member of the steroid and nuclear receptor superfamily, 1
which is composed of over 100 members and continues to grow. Among this large family of …

Benign prostatic hyperplasia (BPH) is a benign enlargement of the prostate in which
incidence increases linearly with age, beginning at about 50 years old. BPH is a significant …

We present GOseq, an application for performing Gene Ontology (GO) analysis on RNA-seq
data. GO analysis is widely used to reduce complexity and highlight biological processes in …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Molecular profiling of cancer at the transcript level has become routine. Large-scale analysis
of proteomic alterations during cancer progression has been a more daunting task. Here, we …

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …

The androgen-signaling pathway is critical to the development and progression of prostate
cancer and androgen ablation is a mainstay of therapy for this disease. We performed a …

The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Androgens are critical regulators of prostate differentiation and function, as well as prostate
cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment …

The androgen receptor (AR) mediates the physiologic and pathophysiologic effects of
androgens including sexual differentiation, prostate development, and cancer progression …