Quercetin: its main pharmacological activity and potential application in clinical medicine

D Yang, T Wang, M Long, P Li - Oxidative Medicine and …, 2020 - Wiley Online Library
Quercetin is a flavonoid compound widely present in plants and exhibits a variety of
biological activities. Research on quercetin has shown its potential for medical application …

Therapeutic potential of quercetin: new insights and perspectives for human health

B Salehi, L Machin, L Monzote, J Sharifi-Rad… - ACS …, 2020 - ACS Publications
Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising
bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti …

[HTML][HTML] Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Chemistry and biology of DNA-binding small molecules

A Paul, S Bhattacharya - Current science, 2012 - JSTOR
Regulation of the transcription machinery is one of the many ways to achieve control of gene
expression. This has been done either at the transcription initiation stage or at the …

DNA binders in clinical trials and chemotherapy

A Ali, S Bhattacharya - Bioorganic & medicinal chemistry, 2014 - Elsevier
Cancer has always been a dreadful disease and continues to attract extensive research
investigations. Various targets have been identified to restrain cancer. Among these DNA …

Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes

S Bhattacharya, P Chaudhuri - Current medicinal chemistry, 2008 - ingentaconnect.com
Properties of benzimidazole and its derivatives have been studied for over hundred years;
special interest of researchers triggered by the fact that 5, 6-dimethylbenzimidazole is a …

Therapeutic Potential of Quercetin-Loaded Nanoemulsion against Experimental Visceral Leishmaniasis: In Vitro/Ex Vivo Studies and Mechanistic Insights

SS Das, AK Dubey, PRP Verma, SK Singh… - Molecular …, 2022 - ACS Publications
Visceral leishmaniasis (VL) is one of the most fatal and neglected tropical diseases caused
by Leishmania donovani (L. donovani). The applications of currently available …

[HTML][HTML] Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise

NS Carter, BD Stamper, F Elbarbry, V Nguyen, S Lopez… - Microorganisms, 2021 - mdpi.com
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …

[HTML][HTML] Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target

S Zhang, GS Gerhard - PloS one, 2009 - journals.plos.org
Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent
antimalarial action of artemisinin and its derivatives, although the source and nature of the …

Flavonoids and related compounds in parasitic disease control.

D Kerboeuf, M Riou, F Guégnard - Mini reviews in medicinal …, 2008 - europepmc.org
Flavonoids are natural plant compounds increasingly used in therapeutic applications. Their
large spectrum of activities depends on their structures and cellular targets. Most recent …